Abstract The development of glucagon-like peptide 1 (GLP1) receptor agonists, including semaglutide and tirzepatide, has transformed the clinical management of overweight and obesity
However, when their levels are too high and there are not enough antioxidants, free radicals can begin to damage DNA, proteins, and lipid tissues in cells
Unsurprisingly, it has been estimated that healthcare expenditure of European countries for overweight, obesity and related comorbidities might require approximately 8% of total national budgets between 2020 and 2050 4
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The participation of transition metal ions in the free radical generation is protected by several metal-sequestering proteins (e.g